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April
2000
Walking With Labor Epidural Analgesia: The Impact of Bupivacaine
Concentration and a Lidocaine-Epinephrine Test Dose.
Cohen SE, Yeh JY, Edward TR, Tracey MV.
Anesthesiology 2000;92:387-92.
Commentary by Peter
Dwane, M.D.
Return to the Current Literature
Review Front Page
[ see abstract below ]
This careful,
well planned study demonstrates that 15 mL of 0.125% bupivacaine with
10 µg sufentanil results in adequate analgesia within 20 minutes
of epidural establishment, and will allow 90% of parturients to ambulate
at some point during their labor. The information is useful for this specific
recipe of local anesthetic and narcotic drug mass and the 15 mL volume
of solution, and it may help a practitioner understand and choose a mixture
to achieve analgesia and ambulation during labor.
The test dose can alter the initial effect of local
anesthetic/narcotic mixture that is infused. In this study, a 3-mL 1.5%
lidocaine-epinephrine test dose used with the more concentrated bupivacaine
0.125% did reduce the incidence of ambulation in patients at 30 minutes,
although there was no difference later on.
There was no difference in overall satisfaction for
analgesia, nor for walking among any of the treatment groups. Overall
satisfaction was measured using a verbal scale of 0 to 10, where 0 = completely
dissatisfied and 10 = extremely satisfied. Cohen states: "Satisfaction
with analgesia was high in all groups (range of mean scores, 9-9.4) with
no differences among the groups. Similarly, satisfaction scores for walking
did not differ among the groups (range of mean scores, 6-7.5)." This isn't
surprising because most laboring patients request epidurals for pain relief.
However, even with the high incidence of ambulation in this study, the
walking satisfaction score was somewhat reduced compared to the analgesic
satisfaction score. Could it be that the term "walking epidural" conveys
to parturients unrealistic expectations of how they will be able to function
during their labor? Do they expect to have analgesia but totally normal
motor function?
In this study the parturients were allowed to walk before
applying various motor and sensory tests which are often used as predictors
of safe ambulation. This sequence of walking and then testing may account
for the higher ambulation rate in this study when compared with other
studies. At the same time this sequence may indicate that certain of these
predictors of safe ambulating are in fact too conservative, or at least
not precise enough to define who may safely ambulate after a neuraxial
block. And this is suggested by the fact that 37% of patients who could
not perform deep knee bends (90°) after epidural establishment were
able to walk safely.
ABSTRACT
Walking
with labor epidural analgesia: the impact of bupivacaine concentration and
a lidocaine-epinephrine test dose.
AUTHORS:Cohen SE; Yeh JY; Riley ET; Vogel TM.
SOURCE: Anesthesiology. 2000 Feb;92(2):387-92
ABSTRACT:
BACKGROUND: Regional analgesia techniques for labor that permit ambulation
are popular among parturients. This study evaluated the influence of bupivacaine
bolus concentration and a 3-ml 1.5% lidocaine-epinephrine test dose, on
analgesic effectiveness and the ability to walk after block placement.
METHODS: Using a randomized double-blind study design, epidural analgesia
was initiated in 60 parturients undergoing labor as follows: Group TD/B.0625
received a 3-ml lidocaine-epinephrine test dose + 12 ml bupivacaine, 0.0625%;
group TD/B.125 received a 3-ml test dose + 12 ml bupivacaine, 0.125%; group
B.0625 received 15 ml bupivacaine, 0.0625% (no test dose); and group B.125
received 15 ml bupivacaine, 0.125% (no test dose). Initial boluses in all
groups contained 10 microg sufentanil. Bupivacaine, 0.0625%, with 0.33 microg/ml
sufentanil was infused throughout labor at 13.5-15 ml/h. Analgesia balance,
proprioception, motor block, and patient ability to stand and walk were
evaluated at various intervals.
RESULTS: A bolus of 0.125% bupivacaine containing sufentanil, without
a previous test dose, proved to be optimal with respect to analgesia and
early ambulation. When a test dose was given before bupivacaine, 0.125%,
fewer women walked within 1 h of block placement. Bupivacaine, 0.0625%,
with sufentanil, with or without a test dose, provided inadequate analgesia,
necessitating additional bupivacaine, which impaired the ability to walk.
A high percentage of women in all groups (73-93%) walked at some stage during
labor.
CONCLUSION: Omitting a lidocaine-epinephrine test dose and using
0.125% bupivacaine for the initial bolus should permit ambulation in the
early postblock period for most parturients who elect this option.
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