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April 2000

Walking With Labor Epidural Analgesia: The Impact of Bupivacaine Concentration and a Lidocaine-Epinephrine Test Dose.

Cohen SE, Yeh JY, Edward TR, Tracey MV.
Anesthesiology 2000;92:387-92.

Commentary by Peter Dwane, M.D.

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[ see abstract below ]

This careful, well planned study demonstrates that 15 mL of 0.125% bupivacaine with 10 µg sufentanil results in adequate analgesia within 20 minutes of epidural establishment, and will allow 90% of parturients to ambulate at some point during their labor. The information is useful for this specific recipe of local anesthetic and narcotic drug mass and the 15 mL volume of solution, and it may help a practitioner understand and choose a mixture to achieve analgesia and ambulation during labor.

The test dose can alter the initial effect of local anesthetic/narcotic mixture that is infused. In this study, a 3-mL 1.5% lidocaine-epinephrine test dose used with the more concentrated bupivacaine 0.125% did reduce the incidence of ambulation in patients at 30 minutes, although there was no difference later on.

There was no difference in overall satisfaction for analgesia, nor for walking among any of the treatment groups. Overall satisfaction was measured using a verbal scale of 0 to 10, where 0 = completely dissatisfied and 10 = extremely satisfied. Cohen states: "Satisfaction with analgesia was high in all groups (range of mean scores, 9-9.4) with no differences among the groups. Similarly, satisfaction scores for walking did not differ among the groups (range of mean scores, 6-7.5)." This isn't surprising because most laboring patients request epidurals for pain relief. However, even with the high incidence of ambulation in this study, the walking satisfaction score was somewhat reduced compared to the analgesic satisfaction score. Could it be that the term "walking epidural" conveys to parturients unrealistic expectations of how they will be able to function during their labor? Do they expect to have analgesia but totally normal motor function?

In this study the parturients were allowed to walk before applying various motor and sensory tests which are often used as predictors of safe ambulation. This sequence of walking and then testing may account for the higher ambulation rate in this study when compared with other studies. At the same time this sequence may indicate that certain of these predictors of safe ambulating are in fact too conservative, or at least not precise enough to define who may safely ambulate after a neuraxial block. And this is suggested by the fact that 37% of patients who could not perform deep knee bends (90°) after epidural establishment were able to walk safely.


ABSTRACT



Walking with labor epidural analgesia: the impact of bupivacaine concentration and a lidocaine-epinephrine test dose.

AUTHORS:Cohen SE; Yeh JY; Riley ET; Vogel TM.

SOURCE: Anesthesiology. 2000 Feb;92(2):387-92

ABSTRACT:

BACKGROUND: Regional analgesia techniques for labor that permit ambulation are popular among parturients. This study evaluated the influence of bupivacaine bolus concentration and a 3-ml 1.5% lidocaine-epinephrine test dose, on analgesic effectiveness and the ability to walk after block placement.

METHODS: Using a randomized double-blind study design, epidural analgesia was initiated in 60 parturients undergoing labor as follows: Group TD/B.0625 received a 3-ml lidocaine-epinephrine test dose + 12 ml bupivacaine, 0.0625%; group TD/B.125 received a 3-ml test dose + 12 ml bupivacaine, 0.125%; group B.0625 received 15 ml bupivacaine, 0.0625% (no test dose); and group B.125 received 15 ml bupivacaine, 0.125% (no test dose). Initial boluses in all groups contained 10 microg sufentanil. Bupivacaine, 0.0625%, with 0.33 microg/ml sufentanil was infused throughout labor at 13.5-15 ml/h. Analgesia balance, proprioception, motor block, and patient ability to stand and walk were evaluated at various intervals.

RESULTS: A bolus of 0.125% bupivacaine containing sufentanil, without a previous test dose, proved to be optimal with respect to analgesia and early ambulation. When a test dose was given before bupivacaine, 0.125%, fewer women walked within 1 h of block placement. Bupivacaine, 0.0625%, with sufentanil, with or without a test dose, provided inadequate analgesia, necessitating additional bupivacaine, which impaired the ability to walk. A high percentage of women in all groups (73-93%) walked at some stage during labor.

CONCLUSION: Omitting a lidocaine-epinephrine test dose and using 0.125% bupivacaine for the initial bolus should permit ambulation in the early postblock period for most parturients who elect this option.
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